To avoid work zones with 2-way traffic
St. Louis to Springfield
Take Westbound I-44 to Exit 186 at Rolla. Turn left onto US 63 South. Take US 63 about 65 miles to Cabool. Turn right onto US 60 West. Take US 60 West about 70 miles to Springfield. Continue West on US 60 then MO 360 about 10 miles to I-44 West of Springfield at Exit 69.
Springfield to St. Louis
Take Eastbound I-44 to Exit 69 west of Springfield. Take MO 360 East then US 60 East about 10 miles through Springfield. Continue on US 60 East about 70 miles to US 63 North at Cabool. Take US 63 North about 65 miles to I-44 at Rolla. Return to I-44 East at Exit 186 in Rolla.